In today’s world, it is hard to image innovation without interdisciplinary teamwork. The growing proportion of software in products is a key driver for innovative products. This gives rise to an enormous number of dependencies between disciplines and their work products within the development process. This white paper shows how Model-Based Systems Engineering (MBSE) can simplify and accelerate the development process. Also highlights why it is worth integrating MBSE and Product Lifecycle Management (PLM). It is widely accepted that the potential of MBSE can only be fully exploited if it is integrated in a collaborative environment by means of robust processes. This is exactly where the intrinsic strengths of PLM lie.